- ILD
- more than 200 lung diseases
- UIPis the radiological correlate of IPF
- idiopathic pulmonary fibrosis (IPF) is the most frequent
- key radiololgy features
- Subpleural and basal prese
- traction bronchiolectasis
- Others
- irregular reticulation,
- honeycombing,
- clusters of cystic airspaces of
- consistent diameter
- multiple layers of
- subpleural cysts
- on top of each other
- pleural thickening . especially when associated with the presence of honeycomb cysts
- Ground-glass opacification,
- not a typical feature of IPF
- but can be seen in early disease.
-
- Note
- Traction bronchiectasis/ bronchiolectasis
- honeycombing are not always present,
- making diagnosis of IPF difficult.
- In addition,
- UIP is also seen in other lung diseases
- like hypersensitivity pneumonitis,
- drug-induced lung disease and some
- collagen vascular diseases
- thus need for
- multidisciplinary discussion.
- Key Pathology features
-
- predominantly subpleural
- paraseptal regions of
- dense fibrosis with
- yalinized collagen
- destruction the alveolar architecture, and presents with
- mild inflammatory infiltrate
- honeycomb changes characterized by formation of
- cystic airspaces of varying size
- filled with mucus, and
- lined by bronchiolar epithelium
- myofibroblasts
- adjacent to advanced fibrotic regions. I
-
- Strata of Dx
- A definite diagnosis
- marked fibrosis with
- architectural destruction,
- patchy involvement and
- fibroblast foci
-
- Not UIP
- presence of granulomas,
- marked inflammation outside fibrotic regions,
- hyaline membranes,
- preferential airway-centered involvement and
- organizing pneumonia,
References and Links
Attili, A.K etal Smoking-related Interstitial Lung Disease: Radiologic-Clinical-Pathologic Correlation RadioGraphics Vol. 28, No. 5
Gupta et al Diffuse Cystic Lung Disease: Part I American Journal of Respiratory and Critical Care Medicine 191(12) April 2015
TCV
TCV
- Idiopathic Pulmonary Fibrosis
- Interstitial Lung Disease and Emphysema
- Interstitial Lung Disease ILD and Scleroderma
- Interstitial Lung Disease, ILD and Connective Tissue Disease
- Interstitial Lung Disease, ILD and Pulmonary Hypertension, PHA
- Interstitial Lung Disease, ILD, and Rheumatoid Arthritis , RA
- Interstitial Lung Disease, ILD, Usual Interstitial Lung Disease, UIP
- Interstitial Lung Disease, IPF, and Hiatus hernia
- Interstitial Lung Diseases
- Interstitial Pneumonias, ILD
DOMElement Object
(
[schemaTypeInfo] =>
[tagName] => table
[firstElementChild] => (object value omitted)
[lastElementChild] => (object value omitted)
[childElementCount] => 1
[previousElementSibling] =>
[nextElementSibling] =>
[nodeName] => table
[nodeValue] =>
Lung Disease and Cigarette Smoking
Respiratory Bronchiolitis
Desquamative Interstitial Pneumonia
Pulmonary Langerhans Cell Histiocytosis
Emphysema
Airspace Enlargement and Fibrosis
Idiopathic Pulmonary Fibrosis
[nodeType] => 1
[parentNode] => (object value omitted)
[childNodes] => (object value omitted)
[firstChild] => (object value omitted)
[lastChild] => (object value omitted)
[previousSibling] => (object value omitted)
[nextSibling] => (object value omitted)
[attributes] => (object value omitted)
[ownerDocument] => (object value omitted)
[namespaceURI] =>
[prefix] =>
[localName] => table
[baseURI] =>
[textContent] =>
Lung Disease and Cigarette Smoking
Respiratory Bronchiolitis
Desquamative Interstitial Pneumonia
Pulmonary Langerhans Cell Histiocytosis
Emphysema
Airspace Enlargement and Fibrosis
Idiopathic Pulmonary Fibrosis
)
DOMElement Object
(
[schemaTypeInfo] =>
[tagName] => td
[firstElementChild] => (object value omitted)
[lastElementChild] => (object value omitted)
[childElementCount] => 1
[previousElementSibling] =>
[nextElementSibling] =>
[nodeName] => td
[nodeValue] => Idiopathic Pulmonary Fibrosis
[nodeType] => 1
[parentNode] => (object value omitted)
[childNodes] => (object value omitted)
[firstChild] => (object value omitted)
[lastChild] => (object value omitted)
[previousSibling] => (object value omitted)
[nextSibling] => (object value omitted)
[attributes] => (object value omitted)
[ownerDocument] => (object value omitted)
[namespaceURI] =>
[prefix] =>
[localName] => td
[baseURI] =>
[textContent] => Idiopathic Pulmonary Fibrosis
)
DOMElement Object
(
[schemaTypeInfo] =>
[tagName] => td
[firstElementChild] => (object value omitted)
[lastElementChild] => (object value omitted)
[childElementCount] => 1
[previousElementSibling] =>
[nextElementSibling] =>
[nodeName] => td
[nodeValue] => Airspace Enlargement and Fibrosis
[nodeType] => 1
[parentNode] => (object value omitted)
[childNodes] => (object value omitted)
[firstChild] => (object value omitted)
[lastChild] => (object value omitted)
[previousSibling] => (object value omitted)
[nextSibling] => (object value omitted)
[attributes] => (object value omitted)
[ownerDocument] => (object value omitted)
[namespaceURI] =>
[prefix] =>
[localName] => td
[baseURI] =>
[textContent] => Airspace Enlargement and Fibrosis
)
DOMElement Object
(
[schemaTypeInfo] =>
[tagName] => td
[firstElementChild] => (object value omitted)
[lastElementChild] => (object value omitted)
[childElementCount] => 1
[previousElementSibling] =>
[nextElementSibling] =>
[nodeName] => td
[nodeValue] => Emphysema
[nodeType] => 1
[parentNode] => (object value omitted)
[childNodes] => (object value omitted)
[firstChild] => (object value omitted)
[lastChild] => (object value omitted)
[previousSibling] => (object value omitted)
[nextSibling] => (object value omitted)
[attributes] => (object value omitted)
[ownerDocument] => (object value omitted)
[namespaceURI] =>
[prefix] =>
[localName] => td
[baseURI] =>
[textContent] => Emphysema
)
DOMElement Object
(
[schemaTypeInfo] =>
[tagName] => td
[firstElementChild] => (object value omitted)
[lastElementChild] => (object value omitted)
[childElementCount] => 1
[previousElementSibling] =>
[nextElementSibling] =>
[nodeName] => td
[nodeValue] => Pulmonary Langerhans Cell Histiocytosis
[nodeType] => 1
[parentNode] => (object value omitted)
[childNodes] => (object value omitted)
[firstChild] => (object value omitted)
[lastChild] => (object value omitted)
[previousSibling] => (object value omitted)
[nextSibling] => (object value omitted)
[attributes] => (object value omitted)
[ownerDocument] => (object value omitted)
[namespaceURI] =>
[prefix] =>
[localName] => td
[baseURI] =>
[textContent] => Pulmonary Langerhans Cell Histiocytosis
)
DOMElement Object
(
[schemaTypeInfo] =>
[tagName] => td
[firstElementChild] => (object value omitted)
[lastElementChild] => (object value omitted)
[childElementCount] => 1
[previousElementSibling] =>
[nextElementSibling] =>
[nodeName] => td
[nodeValue] => Desquamative Interstitial Pneumonia
[nodeType] => 1
[parentNode] => (object value omitted)
[childNodes] => (object value omitted)
[firstChild] => (object value omitted)
[lastChild] => (object value omitted)
[previousSibling] => (object value omitted)
[nextSibling] => (object value omitted)
[attributes] => (object value omitted)
[ownerDocument] => (object value omitted)
[namespaceURI] =>
[prefix] =>
[localName] => td
[baseURI] =>
[textContent] => Desquamative Interstitial Pneumonia
)
DOMElement Object
(
[schemaTypeInfo] =>
[tagName] => td
[firstElementChild] => (object value omitted)
[lastElementChild] => (object value omitted)
[childElementCount] => 1
[previousElementSibling] =>
[nextElementSibling] =>
[nodeName] => td
[nodeValue] => Respiratory Bronchiolitis
[nodeType] => 1
[parentNode] => (object value omitted)
[childNodes] => (object value omitted)
[firstChild] => (object value omitted)
[lastChild] => (object value omitted)
[previousSibling] => (object value omitted)
[nextSibling] => (object value omitted)
[attributes] => (object value omitted)
[ownerDocument] => (object value omitted)
[namespaceURI] =>
[prefix] =>
[localName] => td
[baseURI] =>
[textContent] => Respiratory Bronchiolitis
)
DOMElement Object
(
[schemaTypeInfo] =>
[tagName] => td
[firstElementChild] => (object value omitted)
[lastElementChild] => (object value omitted)
[childElementCount] => 1
[previousElementSibling] =>
[nextElementSibling] =>
[nodeName] => td
[nodeValue] =>
Lung Disease and Cigarette Smoking
[nodeType] => 1
[parentNode] => (object value omitted)
[childNodes] => (object value omitted)
[firstChild] => (object value omitted)
[lastChild] => (object value omitted)
[previousSibling] => (object value omitted)
[nextSibling] => (object value omitted)
[attributes] => (object value omitted)
[ownerDocument] => (object value omitted)
[namespaceURI] =>
[prefix] =>
[localName] => td
[baseURI] =>
[textContent] =>
Lung Disease and Cigarette Smoking
)