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Acute phase diffuse alveolar damage

Han and Fan..

  • hospital admission
    • 6 months later.
      • 62% residual CT abnormalities at 6 months.
        • 35% of the total cohort with ?fibrotic-like?
          • parenchymal bands,
          • irregular interfaces [bronchovascular, pleural, or mediastinal],
          • traction bronchiectasis, and/or honeycombing).
        • remaining participants
          • ground-glass opacification and
          • interstitial thickening;
      • 26% of patients had reduced gas exchange physiology.
    • Important was
      •  link between ARDS and fibrotic-like changes at 6 months
      • The corona virus at 1/100 the size of a human cell, threatens the people on the earth which is 8000 X 1,609,344,000,000 its size.
        Ashley Davidoff TheCommonVein.net
        The corona virus at 1/100 the size of a human cell, threatens the people on the earth which is 8000 X 1,609,344,000,000 its size.
        Ashley Davidoff TheCommonVein.net
        INHALATION
        The virus enters the lungs and travels to the smallest parts of the lungs, tiny lung sacs called the alveoli where oxygen exchange takes place
        Ashley Davidoff TheCommonVein.net
        CELLULAR INVASION
        Corona virus invades the cells of the alveoli by using its spike glycoproteins. These spike proteins attach to the cell membrane and the virus can then enter the cell.
        Ashley Davidoff TheCommonVein.net
        CELLULAR INVASION
        Corona virus invades the cells of the alveoli by using its spike glycoproteins. These spike proteins attach to the cell membrane and the virus can then enter the cell.
        Ashley Davidoff TheCommonVein.net
        INFLAMMATION
        The virus replicates and invades more cells of the alveoli
        As COVID-19 causes inflammation of the the lungs, infected fluid fills the lungs thus disrupting gas exchange.
        Ashley Davidoff TheCommonVein.net
        PROGRESSION AS THE DISEASE SPREADS IN THE LUNGS
        The infection starts in small basal segments
        INFLAMMATION
        The virus replicates and invades more cells of the alveoli
        As COVID-19 causes inflammation of the the lungs, infected fluid fills the lungs thus disrupting gas exchange.
        Ashley Davidoff TheCommonVein.net
        PROGRESSION AS THE DISEASE SPREADS IN THE LUNGS
        The infection starts in small basal segments
        Ashley Davidoff TheCommonVein.net
        PROGRESSION
        and progresses to involve more and more lung
        Ashley Davidoff
        PROGRESSION
        and progresses to involve more and more lung
        INITIAL PATCHY INVOLVEMENT
        It spreads to both lungs
        MULTIFOCAL PNEUMONIA
        Advancing infection involves more lung and prevents efficient and effective gas exchange (inhalation of oxygen and expiration of carbon dioxide). When this exchange is not possible, a ventilator is necessary

         

        Extensive Disease With ARDS

        39 COVID 004 current

         

        Organizing Pneumonia

        COVID ILD 9 months post Acute Infection

Wells et al editorial Radiology