Amyloid deposits in the trachea and bronchi, leading to wall thickening and luminal narrowing.
Submucosal Deposits:
Amyloid deposits beneath the mucosa of the trachea and bronchi, contributing to airway compromise.
Nodular or Mass-like Lesions:
Formation of nodules or mass-like lesions in the lung parenchyma due to amyloid deposits.
Pulmonary Parenchymal Involvement:
Amyloid deposition in the lung parenchyma, leading to diffuse or focal interstitial infiltrates.
Ground-Glass Opacities (GGOs):
Areas of ground-glass opacities on imaging studies, reflecting parenchymal involvement.
Septal Thickening
Pleural Involvement:
Amyloid deposition in the pleura, leading to pleural thickening or effusion in some cases.
Mediastinal Lymphadenopathy:
Enlarged lymph nodes in the mediastinum, due to amyloid deposits can calcify.
Involvement of the mediastinum, including lymph nodes, may occur in some cases of amyloidosis.
Extracellular deposition
insoluble proteins
Lung
Perivascular and peribronchiolar infiltration of amorphous acellular infiltration of pink amyloid in a mouse model NIH National Toxicology Program The diagram shows infiltration of dark pink, amorphous, acellular amyloid deposition In the wall of the arteriole Ashley Davidoff TheCommonVein.net A normal bronchiole usually 1mm or less in diameter. The wall consists of ciliated cuboidal epithelium and a layer of smooth muscle. Bronchioles divide into even smaller bronchioles, called terminal bronchioles, which are 0.5 mm or less in diameter and are primarily lined by club cells, and accompanied by a small number of ciliated cuboidal cells.. Respiratory bronchioles are the final division of the bronchioles within the lung and they are .5mm or less in diameter and contain a simple non ciliated cuboidal epithelium and a thin layer of smooth muscle Ashley Davidoff MD TheCommonVein.net lungs-0721 The diagram shows infiltration of dark pink, amorphous, acellular amyloid deposition In the wall of the bronchiole Ashley Davidoff TheCommonVein.net
The Largest Bronchocentric Mass with Calcification 83 y.o. male with biopsy proven nodular lung AL amyloidosis diagnosed by lung biopsy 5 years ago . His underlying amylogenic protein was typed by liquid chromatography mass spectrometry as kappa. Ashley Davidoff TheCommonVein.net The Largest Bronchocentric Mass with Calcification 83 y.o. male with biopsy proven nodular lung AL amyloidosis diagnosed by lung biopsy 5 years ago . His underlying amylogenic protein was typed by liquid chromatography mass spectrometry as kappa. Ashley Davidoff TheCommonVein.net
Nodular Form that may
calcify,
cavitate, and
slowly enlarge.
Small non descript nodule in a 65 year old female with path proven lung amyloid Ashley Davidoff MD TheCommonVein.net Small non descript nodule in a 65 year old female with path proven lung amyloid Ashley Davidoff MD TheCommonVein.net
Diffuse alveolar-septal amyloidosis CT scan in the axial projection at the base of the lungs show many features of amyloidosis including lung nodules (white arrowheads) and infiltrates (b), and diffuse deposition within the alveolar septa (red arrowheads, c) and centrilobular nodules(yellow arrow c) Ashley Davidoff TheCommonVein.net
consolidations, or
Nodular form
solitary or
Pleural involvement most commonly manifests as
pleural effusions.
nodules
Pleural and Fissural based Nodules some with Calcification 83 y.o. male with biopsy proven nodular lung AL amyloidosis diagnosed by lung biopsy 5 years ago . His underlying amylogenic protein was typed by liquid chromatography mass spectrometry as kappa. Ashley Davidoff TheCommonVein.net AL Amyloid with calcified micronodules on the pleural surfaces Ashley Davidoff TheCommonVein.net AL Amyloid with calcified micronodules Ashley Davidoff TheCommonVein.net AL Amyloid with calcified micronodules Ashley Davidoff TheCommonVein.net
AL Amyloid with calcified micronodules Ashley Davidoff TheCommonVein.net
Mediastinal and hilar lymph nodes may
enlarge and
frequently calcify.
AL Amyloid with calcified micronodules Ashley Davidoff TheCommonVein.net AL Amyloid with calcified micronodules Ashley Davidoff TheCommonVein.net AL Amyloid with calcified micronodules Ashley Davidoff TheCommonVein.net AL Amyloid with calcified micronodules Ashley Davidoff TheCommonVein.net
Soft Tissue Infiltration
CT Alveolar Septal Amyloidosis with Dystrophic Calcifications and Soft Tissue Changes 56 -year-old female with a history of amyloidosis (AL) presents for follow up. Axial CT of the chest shows diffuse soft tissue changes with thickening of the subcutaneous tissues in the right axilla and to lesser extent the left axilla surrounding the left lobe of the thyroid gland and in the subpectoral regions. There is a punctate dystrophic calcification in the right subpectoral region Ashley Davidoff MD TheCommonVein.net 244 Lu 135741d05 CT Alveolar Septal Amyloidosis with Dystrophic Calcifications and Soft Tissue Changes 56 -year-old female with a history of amyloidosis (AL) presents for follow up. Axial CT of the chest shows diffuse soft tissue changes with thickening of the subcutaneous tissues in the right axilla and to lesser extent the left axilla, and in the anterior superior mediastinum Ashley Davidoff MD TheCommonVein.net 244 Lu 135741d06 CT Alveolar Septal Amyloidosis with Calcifications 56 -year-old female with a history of amyloidosis (AL) presents for follow up. Axial CT of the chest shows diffuse reticular process best appreciated anteriorly with thickening of the interlobular septa. Punctate, dystrophic calcifications are seen in the interlobular septa (white arrowheads a, c and d), as well as in the pleura abutting the mediastinum (white arrowhead a). Image b shows similar calcifications, likely deposits of amyloid in the axilla with surrounding soft tissue changes Ashley Davidoff MD TheCommonVein.net 244 Lu 135741d02cL
CT Alveolar Septal Amyloidosis Soft Tissue Calcifications 56 -year-old female with a history of amyloidosis (AL) presents for follow up. Axial CT of the chest shows punctate, dystrophic calcifications in the left upper lobe, pleura abutting the mediastinum and in the right axilla (white arrowheads). There is induration in the soft tissues suggesting amyloidosis (maroon arrowheads). Ashley Davidoff MD TheCommonVein.net 244 Lu 135741d02m05L
manifestation of lymphocytic interstitial pneumonia in Sjögren syndrome
or a manifestation of amyloidosis (possibly due to small airway obstruction by amyloid deposits)
NODULAR FORM OF PULMONARY AMYLOIDOSIS 67 year old female with a nodular form of pulmonary amyloidosis characterised parenchymal calcified nodules, many of which have cystic changes around the nodules. Courtesy Geraldine Tran MD
NODULAR FORM OF PULMONARY AMYLOIDOSIS
67 year old female with a nodular form of pulmonary amyloidosis characterised parenchymal calcified nodules, many of which have cystic changes around the nodules.
Courtesy Geraldine Tran MD
NODULAR FORM OF PULMONARY AMYLOIDOSIS 67 year old female with a nodular form of pulmonary amyloidosis characterised parenchymal calcified nodules, many of which have cystic changes around the nodules. Courtesy Geraldine Tran MD NODULAR FORM OF PULMONARY AMYLOIDOSIS 67 year old female with a nodular form of pulmonary amyloidosis characterised parenchymal calcified nodules, many of which have cystic changes around the nodules. Courtesy Geraldine Tran MD
Likely Sjogren’s Cystic Lung Disease and Amyloid
Stable Cystic Changes 47 F SLE Sjogrens LIP vs Birt-Hogg-Dube basilar thin walled cysts lymphadenopathy Subsegmental right lower lobe infiltrate Ashley Davidoff TheCommonVein.net Stable Calcification in a Cyst ? Amyloid 47 F SLE Sjogrens LIP vs Birt-Hogg-Dube basilar thin walled cysts lymphadenopathy Subsegmental right lower lobe infiltrate Ashley Davidoff TheCommonVein.net Stable Calcification in a Cyst ? Amyloid 47 F SLE Sjogrens LIP vs Birt-Hogg-Dube basilar thin walled cysts lymphadenopathy Subsegmental right lower lobe infiltrate Ashley Davidoff TheCommonVein.net
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Imaging Finding
Description
Tracheobronchial Involvement:
Amyloid deposits in the trachea and bronchi, leading to wall thickening and luminal narrowing.
Submucosal Deposits:
Amyloid deposits beneath the mucosa of the trachea and bronchi, contributing to airway compromise.
Nodular or Mass-like Lesions:
Formation of nodules or mass-like lesions in the lung parenchyma due to amyloid deposits.
Pulmonary Parenchymal Involvement:
Amyloid deposition in the lung parenchyma, leading to diffuse or focal interstitial infiltrates.
Ground-Glass Opacities (GGOs):
Areas of ground-glass opacities on imaging studies, reflecting parenchymal involvement.
Septal Thickening
Pleural Involvement:
Amyloid deposition in the pleura, leading to pleural thickening or effusion in some cases.
Mediastinal Lymphadenopathy:
Enlarged lymph nodes in the mediastinum, due to amyloid deposits can calcify.
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Imaging Finding
Description
Tracheobronchial Involvement:
Amyloid deposits in the trachea and bronchi, leading to wall thickening and luminal narrowing.
Submucosal Deposits:
Amyloid deposits beneath the mucosa of the trachea and bronchi, contributing to airway compromise.
Nodular or Mass-like Lesions:
Formation of nodules or mass-like lesions in the lung parenchyma due to amyloid deposits.
Pulmonary Parenchymal Involvement:
Amyloid deposition in the lung parenchyma, leading to diffuse or focal interstitial infiltrates.
Ground-Glass Opacities (GGOs):
Areas of ground-glass opacities on imaging studies, reflecting parenchymal involvement.
Septal Thickening
Pleural Involvement:
Amyloid deposition in the pleura, leading to pleural thickening or effusion in some cases.
Mediastinal Lymphadenopathy:
Enlarged lymph nodes in the mediastinum, due to amyloid deposits can calcify.
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