72 year old Asian female with multiple microcysts or nodular calcifications in a capsular or subcapsular location. Consequence of lithium therapy is the most likely diagnosis Ashley Davidoff MD 018 72F Asian renal capsular calcification
A Second Case
Lithium used in the treatment of bipolar disorder.
renal toxicity
impaired urinary concentrating ability
natriuresis,
renal tubular acidosis,
tubulointerstitial nephritis
progressing to chronic kidney disease and hypercalcemia.
most common adverse effect is
nephrogenic diabetes insipidus, (20-40% of patients within weeks of initiation of Rx.
Lithium nephropathy is uncommon ,occurring in 15% s(3)
Radiology
innumerable micro cysts randomly distributed in BOTH
cortex and medulla or predominantly cortex are
usually 1-2 mm in diameter.
Cysts arise from distal tubular structures and collecting ducts.