Wiki Leonardo da Vinci
Size of the Universe
In this model, the sun is a very tiny speck of dust indeed—a speck less than a three-thousandth of an inch in diameter … Think of the sun as something less than a speck of dust in a vast city, of the earth as less than a millionth part of such a speck of dust, and we have perhaps as vivid a picture as the mind can really grasp of the relation of our home in space to the rest of the universe. —
Sir James Jeans In The Universe Around Us (1953), 96.
Relative Size of Things
structure | size of structure |
coffee bean | 12 X 8mm |
grain of rice | 8 X 2.5mm |
sesame seed | 3 X 2mm |
grain of salt | .5mm |
ameba | 500 microns |
paramecium | 210X60 microns |
human ovum | 130 microns |
photoreceptor |
100 X 2.5 microns |
sperm |
60 X 5 microns |
skin cell |
30 microns |
red cell |
8 microns |
X chromosome |
7 microns |
baker’s yeast |
3 X 4 microns |
E Coli bacterium | 3 X .6 microns |
mitochondrion | 4 X .8 microns |
lysosyme |
.1 micron |
measles virus |
220 nanometers |
influenza virus | 130 nm |
hiv virus | 130 nm |
coated vesicle | 90 nm |
hepatitis virus |
45nm |
rhinovirus | 30nm |
ribosome |
30nm |
ribosome | 30nm |
antibody |
12 nm |
tRNA |
7nm |
phospholipid | .9 X 3.4nm |
methionine |
1100 X 700pm |
adenine |
1300 X 760pm |
glucose |
900pm |
water molecule | 275pm |
carbon atom | 340pm |
References
Carl Sagan http://www.youtube.com/watch?feature=fvwp&v=t4Tst9DZFPI
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The evaluation of size can take many forms. Most the time in medical imaging we consider a linear measurement since it is the easiest for us to measure. Yet other dimensions including mass, weight, velocity, volume, frequency, velocity, and concentration, are in some way a reflection of size as well.
As a reference it is useful top review the size of some normal structures both at a microspcopic level and a anatomic level
capillaries which average 8 microns in diameter but may be as small as 4 microns –
red blood cells (7.8 micron x 2.6 micron biconcave disks) must fold in half to pass, single-file.
average animal cell is 10 -20 microns
human hair is about 80 microns
human eye can see up to 50 microns
sperm 60 X 5 nm
Nuclear-Cytoplasmic Ratio
The normal (left) and the abnormally large nucleus (right)
Two histological sections above show a normal nuclear cytoplasmic ratio of some liver cells on the left and cells with an increased nuclear cytoplasmic ratio on the right indicating malignant change. The experienced eye and mind of the pathologist develops a geshtalt of what the normal ratio. This is a difficult measurement to make objectively.
13440 13447Courtesy Barbara Banner MD
In this instance, making the assessment of an increase in the nuclear to cytoplasmic ratio is of the highest importance in the patient’s prognosis. If the nuclear cytoplasmic ratio is increased then a major criterion in the diagnosis of malignancy is recorded by the pathologist. The distinction between making a diagnosis of life threatening malignancy or not is as simple yet profound as that. It has its basis in the assessment of size.
Many diseases result in structures getting bigger. These encompass a variety of structural changes including neoplasia, hyperplasia, and hypertrophy. Diseases may also be caused by smallness of structure, with examples such as atrophy, hypoplasia, aplasia and atresia. Other disorders that may be associated with smallness include infarctions of the brain or spleen, congenital disorders such as hypoplastic right heart syndrome and esophageal atresia (esophagus is small and not formed) and immune disorders where tissue is destroyed such as sprue, or atrophic gastritis.
Evaluation of the magnitude of structure (and function in many ways) is a fundamental aspect of medicine. It is difficult to have a sense of how size fits into the clinical picture when it is learned in the context of basic science, but it always holds tremendous importance in the clinical realm.
The evaluation of size can take many forms. Most the time in medical imaging we consider a linear measurement since it is the easiest for us to measure. Yet other dimensions including mass, weight, velocity, volume, frequency, velocity, and concentration, are in some way a reflection of size as well
It may be useful to review the size of some common structures both at an anatomic level as well as a microscopic level in order to get a perspective.
The largest organ in the body is the skin, and the largest gland in the body is liver. The liver weighs about 1200 grams. Other large organs include the lungs which by volume are the largest, but by weight are not. The femur is the largest and longest bone in the body. The intermediate size organs include the brain heart, spleen and kidneys. The smaller organs include the pancreas, gallbladder uterus, and smaller than they are ovaries, thyroid and testes. Yet smaller are the adrenal glands, parotids, submandibular glands and the parathyroids.
structure | length | widthant-post | trv | weight | volume | other | comment |
adrenal | 3-5cms | 8gms | |||||
aorta | 3cms proximal1.75cms distal | ||||||
breasts | 30-500gms | ||||||
bile duct | 5mm | CHD at level of right hepatic artery | |||||
brain | 1400gms | 1000-15000mls | |||||
cervix | 2.5cms | 5cms | 2.5cms | ||||
colon | 150cms5ft | 5cms | |||||
duodenum | 25cms | ||||||
esophagus | 25-30cms | 2cms | |||||
fallopian tube | |||||||
femur | |||||||
gallbladder | 8-10cms | 3-4cms | 50-70mls | ||||
heart | 12cms | 6 | 8-9cms | 230-340gms | |||
IVC | |||||||
kidney | 11.25cms | 5-7.5cms | 125-170gms | ||||
liver | 12-15cms | 10-12.5cms | 20-22.5cms | 1200-1800gms | largest gland in the body accounting for 2% of body weight and aslo the largest abdominal organ | ||
lungs | 24cms | 630gms right570gms left900-1200gms | 4200-6300mls | 40% to 50% of the weight is bloodthe right lung is slightly heavier than the left lung | |||
lymph node | <1cms | ||||||
ovary | 2.5-5cms | 1.5-3cms | 1.5-3cms | 3-18mls | |||
pancreas | 12-15cms | 1.5-3cms | 60-100gms | ||||
pancreatic duct | 1-3mms | ||||||
parathyroid | |||||||
pituitary | 8-9mms | ||||||
prostate | |||||||
pulmonary vein | |||||||
pulmonary artery | |||||||
spinal cord | |||||||
spleen | 12cms | 7cms | 4cms | 80-300gms | 250-350mls | ||
small bowel | 700cms23feet | 2.5cms | |||||
stomach | |||||||
thyroid | 4-6cms | 1-2cms | 2-3cms | 10-20gms | |||
testis | 5cms | 3cms | 2cms | 15-20ccs | |||
trachea | 2cms | ||||||
ureter | 25-30cms | ||||||
urethra | 4cms F17-20cms M | 6mms | |||||
urinary bladder | 12cms | 250 – 500mls | |||||
uterus | 5-8cms | 1.5-3cms | 2.5-5cms | ||||
vein | |||||||
Fom Freitas RA Junior Nanomedicine Volume 1 Basic Capabilities
Philip B. Hawk, Bernard L. Oser, William H. Summerson, Practical Physiological Chemistry, 12th Edition, The Blakiston Company, New York NY, 1951.
Peter L. Williams, Roger Warwick, Mary Dyson, Lawrence H. Bannister, eds., Gray’s Anatomy, Thirty-Seventh Edition, Churchill Livingstone, New York, 1989.
International Commission on Radiation Protection, Committee II, 1959, “Permissible Dose for Internal Radiation,” Health Phys. 3(1960):1.
Ivan Damjanov, James Linder, Anderson’s Pathology, Tenth Edition, Mosby, St. Louis MO, 1996.
capillaries which average 8 microns in diameter but may be as small as 4 microns –
red blood cells (7.8 micron x 2.6 micron biconcave disks) must fold in half to pass, single-file.
average animal cell is 10 -20 microns
human hair is about 80 microns
human eye can see up to 50 microns
sperm 60 X 5 nm
bacteria are as small as 1 micron
E Coli = 2micrometers long
ribosome 25nm diameter
cell membrane = 7.5-10nm thick
DNA molecule is about 2nanometers thick (nano = 1 billionth of a meter)
hydrogen atom = .1nanometer in diameter
0.1 nm (nanometer) diameter of a hydrogen atom
0.8 nm Amino Acid
2 nm Diameter of a DNA Alpha helix
4 nm Globular Protein
6 nm microfilaments
10 nm thickness cell membranes
11 nm Ribosome
25 nm Microtubule
50 nm Nuclear pore
100 nm Large Virus
150-250 nm small bacteria such as Mycoplasma
200 nm Centriole
200 nm (200 to 500 nm) Lysosomes
200 nm (200 to 500 nm) Peroxisomes
800 nm giant virus Mimivirus
1 µm (micrometer)
(1 – 10 µm) the general sizes for Prokaryotes
1 µm Diameter of human nerve cell process
2 µm E.coli – a bacterium
3 µm Mitochondrion
5 µm length of chloroplast
6 µm (3 – 10 micrometers) the Nucleus
9 µm Human red blood cell
10 µm
(10 – 30 µm) Most Eukaryotic animal cells
(10 – 100 µm) Most Eukaryotic plant cells
90 µm small Amoeba
100 µm Human Egg
up to 160 µm Megakaryocyte
up to 500 µm giant bacterium Thiomargarita
up to 800 µm large Amoeba
1 mm (1 millimeter, 1/10th cm)
1 mm Diameter of the squid giant nerve cell
up to 40mm Diameter of giant amoeba Gromia Sphaerica
120 mm Diameter of an ostrich egg (a dinosaur egg was much larger)
3 meters Length of a nerve cell of giraffe’s neck
Reference Wikibooks
interactive relative sizes (Utah)
Principles
Linear Measurements Length Diameter Radius
Size of the Pancreas
41394size002b01 Courtesy Ashley Davidoff MD code pancreas size normal anatomy imaging drawing
Size and Time
71689 ovary follicles normal anatomy function physiology TCV Applied Biology Cycle time USscan Davidoff MD |
Size and Shape
74238c01 88 year old male bilateral complex effusions pleura pleural space atelecactasis space occupation normal 3D volume rendering CTscan Courtey Ashley DAvidoff MD |
45883.800 46133b03 abdomen skin size fx enlarged distended shape CTscan Cortesy Ashley Davidoff MD |
Thickening
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Volume Frequency |
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74242b01 88 year old male emaciated thin 3D volume rendering CTscan Courtey Ashley DAvidoff MD
Volume
Volume Frequency
This diagram outlines the residual volume between the red lines, representing the air that is left in the airways and the alveoli after a full expiration. The air you may see on expiration CXR is the residual volume and as you can see it is about 1.8 liters in this patient. Courtesy Ashley Davidoff MD. 42529b06aa03 |
70294 acv waves hepatic veins doppler tricuspid valve regurgitation TR velocity Ultrasound Echocardiogram Davidoff MD
Weight
02300p.800 scale weight size anatomy structure applied biology Davidoff photography
61229p flower allium size large elongated greater than the 90th percentile abnormally enlarged Davidoff photography
Former Olympian Olga Korbut (C) stands between Manute Bol (L) and William “The Refrigerator” Perry (R) during the weigh-in for Celebrity Boxing 2 in Los Angeles, California Tuesday, May 14, 2002. Korbut will face Darva Conger and Bol will face Perry during the boxing event which will air May 22 on Fox. REUTERS/John Hayes
54916.800
Olga 5feet 1 inch
Manut Bol 7foot 7 inches
William Perry 6’2” 370lbs
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49609c02 abdomen health disease normal obese morbid obesity order disorder Davidoff MD
CNS
Size – Number
72014c01 brain cerebral multicentric infarcts internal capsule parietal lobe cortex dx multicentric infarct left cerebral hemisphere associated with a left carotid stenosis with presumed showering of the embolic material embolism a = DWI b = T2 weighted
CVS
13417 aorta abdomen iliac artery fx atherosclerosis kidney fx small dx RAS renal artery stenosis grosspathology Courtesy Ashley Davidoff MD
42358.800 aorta fx enlarged MPA pulmonary artery aneurysm of the ascending aorta CTscan Davidoff MD
11976c01 aorta abdomen abdominal aorta renal afrteries kidney fx normal AAA abdominal aortic aneurysm horseshoe kidney angogram angiography lumbar arteries Davidoff MD
07953c02 heart cardiac aorta aortic valve fx normal fx thickened fx bicuspid aortic valve fx calcified fx calcification fusion of the intercoronary commisures grossanatomy grosspathology Davidoff MD b Courtesy Henri Cuenoid MD
Size Incompatible with Life
15036c01 Courtesy Ashley Davidoff MD
46786c01 heart cardiac pulmonary arteries arteries fx enlarged fx corkscrew interstitial edema LAE left atrial enlargement dx cardiac failure cardiac congestion CTscan Davidoff MD
Legs and feet seated at a bench in Quincy market in downtown Boston Massachusetts. – What story can you tell? Courtesy Ashley Davidoff MD. 02012p code foot accessory interesting vein varicose age time elderly shoe Davidoff photography
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Davidoff art
Courtesy Ashley Davidoff MD 30672c
47114c01 bronchi lungs fx dilated enlarged impacted with sft tissue finger in glove dx allergic bronchopulomonary aspergillosis ABPA aspergillus dx infection inflammation CTscan Davidoff MD
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73406.800 esophagus narrowing stenosis stricture distal esophageal stricture peptic stricture endoscopy Courtesy Joshua Namias
00136 gallbladder stone large shadowing cholelithiasis imaging radiology USscan
18135.800 46136 Davidoff MD
42649c01 Davidoff art
GUT
46566c01 kidney kidneys size normal small anatomy physiology Davidoff MD
71689 ovary follicles normal anatomy function physiology TCV Applied Biology Cycle time USscan Davidoff MD
46527c01 uterus kidney renal bicornuate uterus single kidney congenital abnormality congenital growth disorder USscan MRI Davidoff MD
70363c09 urinary bladder normal enlarged abdominal pain induration abnormal urinary reterention CTscan sagittal reformat Davidoff MD
uterus fallopian tube distended hydrosalpinx ultrasound USscan 83331.8s Courtesy Ashley Davidoff MD copyright 2009
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Skin
46621 hx 77 year old male with SOB breast pleura fx gynecomastia pleural calcification dx asbestos related disease dx asbestosis CTscan Davidoff MD 46621 46623 46624 46622 |
47017c01 gallbladder fx nodule fx adeherent fx non dependant size character through transmission dx gallbladder polyp Davidoff MD
38078 38078b01 this middle aged female with breast carcinoma skin veins pericardiophrenic veins pericardium pericardial fx collaterals varicocity varicose abdomen ascites dx SVC obstruction imaging radiology CTscan Courtesy Ashley Davidoff MD also code SVC syndrome
48433c01.800 55 F s/p gastric bypass 4 years prior a, c pre bypass b,d post bypass adipose tissue subcutaneous fat size stomach nutrition metabolic fatty liver steatosis morbid obesity gallbladder fossa fatty sparing CTscan Courtesy Ashley Davidoff MD
47752c01 LA heart cardiacmediastinum fx compression of left atrium from anterior post operative nediastinal hematoma and posterior aneurysm of the descending aorta fx lingula atelectatasis and left lower lobe atelectasis bilateral pleural effusions dx supravalvular mitral stenosis CTscan Davidoff MD
46592c01 uterus OB pregnancy fetal demise spontaneous abortion shape size position heart rate USscan Davidoff MD death
Size in Numbers
28980 chest lung spiculated mass satellite nodules malignant carcinoma CTscan Davidoff MD 28979 28980 28981 28984 28985 28986c01
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Ascending Aortic Aneurysm |
42358.800 aorta fx enlarged MPA pulmonary artery aneurysm of the ascending aorta CTscan Davidoff MD |
Malignant Behaviour – Size and Doubling Time
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Growth of a lung lesion over 7 months
48380c01 chest lung fx mass fx growth in 7 months dx metastattic squamous cell carcinoma head and neck primary primary larynx metastasis time size CTscan Davidoff MD 48383c01 48380c01 48383c02 malignant malignancy |
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