The Wisdom of the Thyroid Gland – 

Keep

the Homefires Burning

Ashley Davidoff MD

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The Butterfly Shaped Organ
The butterfly shaped form of the thyroid gland is appreciated in this image.
Ashley Davidoff Copyright 2018
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You are a mere 4 by 2

But have the power to keep our

50-100trillion cells warm and comfy

How do you do it?

What is your wisdom?

In our little earth

In the year 2011 of the rabbit

We only have around 7 billion

And about half of these

Suffer the poverty of food and shelter

In the heat of the winter

Many go cold

And 22,000 of our young ones

Die every day

How do you do what you do?

What is your wisdom?

How do you keep all happy and comfy

And how do you keep the home fires burning?

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Function of the Thyroid by Feedback Mechanisms –
Supply and Demand Principles
Ashley Davidoff Copyright 2018
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In the early days of man

We were ignorant of your simple need

Just a tincture of iodine was your request

Deficient in this dietary substance

Our mountain people

Suffered with ?elephant of the throat?

Mountain Woman with Elephant Throat
Thyroid Goiter
Ashley Davidoff Copyright 2018
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Multinodular Goitre
Ashley Davidoff Copyright 2018
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And their children

With the terrible disease of the cretin

?Deaf and dumb and goiter hanging down to the waist?

Well a little of our wisdom started

Just before the first year of the Rat

In the year around 2700 BC

When the brilliant Emperor Shen Nung

Drank the first cup of tea,

Used the cannabis weed of the earth for gout,

And the weed from the sea to treat elephant throat

Later some said that you ?hang like the scrotum?

And others said you were the size of a ?jubube?

It took da Vinci and Vesalius to draw you,

Eustachian to name your isthmus

And finally Wharton to give you the name of

?Thyreoidea? ? an oblong shield

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?Thyreoidea? ? an oblong shield
Ashley Davidoff Copyright 2018
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Do you think he meant you Mother Shelter?

Or the solid cartilage lying just above you?

Matter not you are truly like mother shield who

Keeps the home fires burning

And everybody warm and comfy

Wang Hei said of the goiter that

Thyroid extract of 50 pigs mixed with cold wine

Would do the trick

Dusault  -tried  a partial extrication of the  maladie

And Dupuytern was warned of your highly flammable vasculature

When he fiddled with your nakedness

While  Reysch went beyond and deep

And found your follicles in the scope of a microlens

Then in France

Coutrois saw iodine in the weed of the sea

Prout recommended the violet chemical for the disease of mountain people

And then and then?

Kendall discovered your magic bullet and called it thyroxine

Now simply as T4

Three tons of animal thyroid yielded but 33gms of the drug

And in 1917 a mere cost of $350 per gram

And at about that time the Model T was selling for about $575

When a wage to make her was about $2.50 per day

So enter Sir Charles Harington of England

The factory line of T4 becomes real

And then enter Rosalind Pitt Rivers also from the Isles of Britain

With yet another magic bullet

This time triiodothyronine

Or simply Miss  T3

So from whence is your wisdom and your magic

You produce a T3 and a T4

Now we know

Simple names for complex function

And we begin to learn that your wisdom reaches further

Hoskins unveils your ?servo mechanism?

Humility in the presence of greater pituitary power

With angel messenger TSH

And you seek no beef

When your horses are held

When production is greater than needed

And you give great feedback

Not too much and not too little but just right, you always seem to say

And then we threw you another curved ball

Straight from the skies came

?Little Boy? to Hiroshima and

?Fat Man? to Nagasaki

And then another ball of fire

In the case of Chernobyl

These events shook the core of your nucleus

And in some cases you had no choice

Other than that of course

It is not always smooth sailing

When your fires burn too fast

Thyrotoxicosis
This diagram shows the structural possibilities in a patient who presents with thyrotoxicosis. Reading from upper left the normal thyroid is shown for reference of size and normal activity (pink). Next is the single toxic nodule that suppresses the function of the gland and the also causes the rest of the gland to shrink. This is followed by a diagram of multiple toxic nodules and the gland in this case may also be smaller than normal. The lower series of images include Grave’s disease, which is the most common cause of thyrotoxicosis, followed by acute thyroiditis and then subacute thyroiditis.
Ashley Davidoff Copyright 2018
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You show the whites of their eyes

And their hands begin to shake

 And all cells are on heat

Exopthalmos and Grave’s Disease
Bilateral exopthalmos or bulging of the eyes is most commonly associated with Grave’s disease which is an autoimmune disease associated with thyrotoxicosis. Upperlid retraction results in the ability to see the whites of the eyes on both sides of the iris.
Ashley Davidoff Copyright 2018
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Beware the rage of thyroid in the eye of the storm

When your fires burn too slow

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The Good Big and Small Thyroid Gland
Hypothyroidism – When Function is no longer there
Ashley Davidoff Copyright 2018
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They speak in low voice

And they always feel the cold and heavy

Beware the calm when the fires are almost out

Cold death from coma is scary

We stand in awe O oblong shield

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The Normal Thyroid
The H shaped form of the thyroid gland is appreciated in this image. The isthmus may be broad in its craniocaudad dimension or may be relativel narrow. In the anetroposterior dimension it is only about 3-5mm thick
Ashley Davidoff Copyright 2018
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The one that keeps the home fires burning

Using unique magic bullets

To keep 50-100 trillion cells

Churning at a comfortable pace

In the heart of winter and heat of the summer

Not too much nor too little, but just right you say

While remaining humble to the greater power?

This is your wisdom

A Gland for all seasons

A Thyroid for All Seasons
A thyroid for all seasons Spring – pink summer green fall orange winter gray
Ashley Davidoff Copyright 2018
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