Cowden Disease is an inherited autosomal dominant disease involving the gastrointestinal mucosa and the skin
characterized by polyps in the small bowel and colon, as well as skin thgyroid and breast disorders,
caused by inherited genetic aberration,
resulting in hamartomas in the colon and small bowel (35-40%), facial trichelemmomas, acral keratoses, oral mucosal papillomatosis, .
Sometimes complicated by breast and thyroid cancer
Diagnosis is suspected clinically by characteristic skin changes, GI bleeding,
Imaging includes the use of endoscopy. Biopsy shows a hamartoma typiccally with nests of ganglion cell s in the lamina propria.
Treatment is symptomatic and surgery as indicated.